International Journal of Stem Cells : eISSN 2005-5447

Table. 2.

Table. 2.

Subgroup analysis to explore source of heterogeneity on changes in LVEF

SubgroupNo. of trials (No. of pts)Mean difference (95% CI)I2
Patients’ characteristics
 AMI6 (524)4.73 (−0.16 to 9.62)90.8
 CMI7 (223)3.66 (1.85 to 5.46)74.7
Cell origin
 Autologous8 (689)4.62 (1.16 to 8.08)90.1
 Allogeneic5 (195)2.78 (0.55 to 5.01)0
Route of delivery
 Intracoronary5 (327)5.30 (0.43 to 10.17)92.4
 Intravenous3 (108)4.87 (0.43 to 8.33)0
 Intramyocardial5 (449)2.96 (1.45 to 4.47)29.7
Measurement tool
 SPECT4 (284)6.40 (1.16 to 11.64)92.1
 MRI3 (145)3.72 (1.87 to 5.56)0
 Echocardiography6 (455)2.34 (0.41 to 4.26)20
Cell differentiation
 Yes4 (394)2.48 (−0.58 to 5.55)48.3
 No9 (490)4.91 (1.66 to 8.17)87
Overall risk of bias
 Low5 (468)3.09 (1.43 to 4.76)0
 High8 (411)6.93 (5.83 to 8.04)89.1

AMI: acute myocardial infarction; CMI: chronic myocardial infarction; SPECT: single-photon emission computed tomography; MRI: magnetic resonance imaging.

International Journal of Stem Cells 2018;11:1-12 https://doi.org/10.15283/ijsc17061
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