International Journal of Stem Cells : eISSN 2005-5447

Fig. 1.

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Fig. 1. RNA-Seq analysis of gene expression changes in BM-MSCs in EAE. (A) Volcano plots depicting differentially expressed genes (DEGs) measured by RNA-Seq analysis of peak EAE-MSCs versus naïve MSCs (left) or chronic EAE-MSCs versus naïve MSCs (right). DEGs were defined by a magnitude fold change of 1.5 or greater, q-value ≤0.05, and a normalized mean expression count ≥10. (B) Unsupervised hierarchical clustering of samples using Pearson correlation with average linkage, along with corresponding dendrogram and heatmap of DEGs. Peak EAE-MSC and chronic EAE-MSC replicates cluster together independently of naïve MSC replicates.
International Journal of Stem Cells 2018;11:48-60 https://doi.org/10.15283/ijsc17062
© 2018 International Journal of Stem Cells