International Journal of Stem Cells : eISSN 2005-5447

Fig. 3.

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Fig. 3. EAE-MSCs show changes in genes associated with inflammation and immune activation. (A) Top 20 gene ontology terms (ranked by p-value) for DEGs found between peak EAE-MSCs and naïve MSCs (left) or chronic EAE-MSCs and naïve MSCs (right). Most GO terms relate to immune processes, particularly immune activation and immune response. (B) Heatmap showing immune genes differentially expressed between peak EAE-MSCs and naïve MSCs (left) or chronic EAE-MSCs and naïve MSCs (right). Many inflammatory genes, including chemokines, cytokines and elements of the complement system, are up regulated in EAE-MSCs.
International Journal of Stem Cells 2018;11:48-60 https://doi.org/10.15283/ijsc17062
© 2018 International Journal of Stem Cells