International Journal of Stem Cells : eISSN 2005-5447

Fig. 5.

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Fig. 5. Changes in gene expression in BM-MSCs throughout EAE. (A) Volcano plot depicting differentially expressed genes (DEGs) measured by RNA-Seq analysis of peak EAE-MSCs versus chronic EAE-MSCs. (B) Top 10 gene ontology (GO) terms ranked by p-value associated with the DEGs found between peak and chronic EAE-MSCs. (C) Heatmap showing immune genes differentially expressed between peak EAE-MSCs and chronic EAE-MSCs. Many inflammatory genes are up regulated in chronic EAE-MSCs compared to peak EAE-MSCs. (D) Venn diagram illustrating similarities in DEGs found between naïve, peak, and chronic EAE-MSCs. (E) Top 10 transcriptional regulators (identified through MetaCore) associated with the DEGs found between peak EAE-MSCs and naïve MSCs (left) or chronic EAE-MSCs and naïve MSCs (right). Transcription factors (TF) are ranked according to their respective z-score (the level of connectivity of the TF to the DEG list), with the number of DEGs associated with that TF indicated above each bar.
International Journal of Stem Cells 2018;11:48-60 https://doi.org/10.15283/ijsc17062
© 2018 International Journal of Stem Cells