International Journal of Stem Cells : eISSN 2005-5447

Fig. 1.

Download original image
Fig. 1. JQ1 synergizes with ATRA to reduce proliferation of AML cells. (A) HL-60 cells and MV4-11 cells were treated with ATRA (20~100 nM) for the indicated days. Cell proliferation was measured using a CCK-8 assay. The data represent the means±SD of 3 independent experiments. *ATRA versus control (***p<0.001). (B) HL-60 cells and MV4-11 cells were treated with the indicated concentrations of JQ1 and/or 100 nM ATRA for 3 days. Cell proliferation was measured using a CCK-8 assay. The data represent the means±SD of 3 independent experiments. *combination versus ATRA (***p<0.001); combination versus JQ1 (†††p<0.001). (C) CDI values at different concentrations of JQ1 and 100 nM ATRA were calculated as described in materials and methods.
International Journal of Stem Cells 2018;11:131-40 https://doi.org/10.15283/ijsc18021
© 2018 International Journal of Stem Cells