International Journal of Stem Cells : eISSN 2005-5447

Fig. 2.

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Fig. 2. G-CSF-mediated ERK5 activation induces the proliferation of AML cells. (A, D) XMD8-92 suppressed the G-CSF-stimulated phosphorylation of ERK5 but not affected ERK1/2 in Kasumi-1 (A) and HL-60 (D) cells. (B, E) PD184352, as an inhibitor of ERK1/2, was not inhibited the G-CSF-stimulated activation of ERK5 in Kasumi-1 (B) and HL-60 (E) cells. (C, F) The cell proliferation induced by with or without G-CSF was suppressed by the treatment of XMD8-92 in Kasumi-1 (C) and HL-60 (F) cells, respectively. Data were obtained from three replicate experiments for the cell counting kit-8 assay. Data represent mean±SD. **p<0.01, ***p<0.005 indicates a significant difference compared to control.
International Journal of Stem Cells 2018;11:227-34 https://doi.org/10.15283/ijsc18053
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