International Journal of Stem Cells : eISSN 2005-5447

Fig. 4.

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Fig. 4. Histological analysis of neonatal hyperoxic lung injury (NHLI) lungs. (A∼E) Compared to normoxia exposure (A), hyperoxia exposure (B) caused capillary expansion and alveolar hyperemia, as well as infiltration of neutrophils. The direct transfusion of cells (C), and the transfusion of exosomes (EXOs) (D) and conditioned media (CM) (E) reduced pulmonary edema. (F) To evaluate the effect of hAD-MSCs on NHLI, we used a 5-level evaluation system. hAD-MSCs, hAD-MSC-EXOs, and hAD-MSC-CM significantly alleviated pulmonary edema, especially in the hAD-MSC-treated group. (G) Mean linear intercept (MLI) values in the five groups. The lung tissue sections were assessed through lung morphometry. The hyperoxia group exhibited significantly higher MLI values than the normoxia and three therapy groups. hAD-MSCs treatment significantly reduced the hyperoxia-induced increase in lung injury scores and MLI values. Magnification: 100×. *p<0.05 vs. Normoxia group, **p<0.01 vs. Normoxia group, #p<0.05 vs. Hyperoxia group, ##p<0.01 vs. Hyperoxia group.
International Journal of Stem Cells 2020;13:221-36 https://doi.org/10.15283/ijsc19110
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