International Journal of Stem Cells : eISSN 2005-5447

Fig. 5.

Download original image
Fig. 5. hAD-MSCs effectively alleviated inflammatory response. Both hAD-MSCs and their derivatives reduced the levels of (A) TNF-α, (B) IL-6, (C) IL-1β, (D) MCP-1, (E) malondialdehyde (MDA), (F) overall proteins, and (G) neutrophils in bronchoalveolar lavage fluid (BALF); these were all increased after hyperoxia exposure. (H) Hyperoxia exposure significantly decreased the expression of superoxide dismutase (SOD) in BALF. Both hAD-MSCs and hAD-MSC-EXOs significantly increased SOD expression, while hAD-MSC-derived conditioned media (CM) did not. *p<0.05 vs. Normoxia group, **p<0.01 vs. Normoxia group, #p<0.05 vs. Hyperoxia group, ##p<0.01 vs. Hyperoxia group.
International Journal of Stem Cells 2020;13:221-36 https://doi.org/10.15283/ijsc19110
© 2020 International Journal of Stem Cells