International Journal of Stem Cells : eISSN 2005-5447

Fig. 4.

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Fig. 4. Effect of DiO and QD labeling on the voltage-dependent Na+ current (INav) and L-type Ca2+ current (ICa,L) in hiPSC-CMs. (A, B) Peak amplitudes of INav were analyzed after replacing Na+ in the extracellular solution with NMDG+. The peak inward current densities recorded in DiO- and QD-labeled CMs compared to unlabeled control CMs at −50 mV. (C, D) Peak amplitudes of ICa,L were analyzed after the application of a selective inhibitor, nifedipine (1 μM). A significant increase in ICa,L was observed in QD-labeled CMs compared to control CMs. All the data were analyzed using paired t-tests, where *p<0.05 was considered statistically significant.
International Journal of Stem Cells 2020;13:287-94 https://doi.org/10.15283/ijsc19138
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