International Journal of Stem Cells All Title Author Keywords Abstract   :: 선택 :: AND OR   International Journal of Stem Cells 2009 Nov; 2(2): 102~108 Stem Cells Transplantation and Huntington's Disease Wooseok Im1, Soon-Tae Lee1,2, Kon Chu1,2, Manho Kim1,2, Jae-Kyu Roh1,2 1Department of Neurology, Clinical Research Institute, Seoul National University Hospital, 2Program in Neuroscience, Neuroscience Research Institute of SNUMRC, Seoul National University, Seoul, Korea Huntington's disease (HD) is a progressive and devastating neurodegenerative disorder that results in movement abnormalities, cognitive impairments, dementia, and affective disturbances. As no proven medical therapy for this genetic disease is currently available, symptoms mitigation is the primary treatment for HD. Stem cells can play an important role in cell therapy therapeutic strategies to replace dysfunctional or dying cells in HD. Here, we present a brief overview of the current state of stem cells therapy and of the results obtained in animal models of HD, and discuss neuroprotective approaches that utilize stem cells-derived paracrine factors. International Journal of Stem Cells 2009 Nov; 2(2): 102~108 Keyword : Stem cells, Animal model, Huntington's disease