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Toward a Reconceptualization of Stem Cells from Cellular Plasticity
International Journal of Stem Cells
Published online February 28, 2019;  
© 2019 Korean Society for Stem Cell Research.

Tao Liu1, Li Chen2, Zhongjian Zhao3, Shichang Zhang3

1Department of Infectious Diseases, Navy No.971 Hospital (formerly known as No.401 Hospital) of Chinese PLA, Qingdao, China, 2Department of Obstetrics, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 3Department of Laboratory Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Correspondence to: Shichang Zhang
Department of Laboratory Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
Tel: +86-25-6830-3773, Fax: +86-25-6830-3773
E-mail: zsc78@yeah.net
Received October 19, 2018; Revised January 21, 2019; Accepted January 21, 2019.
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
The slow progress in clinical applications of stem cells and the bewildering mechanisms involved have puzzled many researchers. Recently, the increasing evidences have indicated that cells have superior plasticity in vivo or in vitro, spontaneously or under extrinsic specific inducers. The concept of stem cells may be challenged, or even replaced by the concept of cell plasticity when cell reprogramming technology is progressing rapidly. The characteristics of stem cells are manifestations of cellular plasticity. Incorrect understanding of the concept of stem cells hinders the clinical application of so-called stem cells. Understanding cellular plasticity is important for understanding and treating disease. The above issues will be discussed in detail to prove the reconceptualization of stem cells from cellular plasticity.
Keywords : Stem cells, Plasticity, Differentiation, Dedifferentiation, Transdifferentiation


February 2019, 12 (1)