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Hematopoietic Stem Cells and Their Roles in Tissue Regeneration
International Journal of Stem Cells
Published online December 31, 2019;  
© 2019 Korean Society for Stem Cell Research.

Ji Yoon Lee1, Seok-Ho Hong2

1CHA Advanced Research Institute, CHA University, Seongnam, Korea
2Department of Internal Medicine, School of Medicine, Kangwon National University, Chuncheon, Korea
Correspondence to: Seok-Ho Hong
Department of Internal Medicine, School of Medicine, Kangwon National University, 1 Gangwondaehak-gil, Chuncheon 24341, Korea
Tel: +82-33-250-7819, Fax: +82-33-244-2367
Received October 12, 2019; Revised November 18, 2019; Accepted December 1, 2019.
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background and Objectives: Hematopoietic stem cells (HSCs) are regarded as one of essential cell sources for treating regenerative diseases. Among many stem cells, the feasibility of using adult-derived hematopoietic stem cells in therapeutic approaches is very diverse, and is unarguably regarded as an important cell source in stem cell biology. So far, many investigators are exploring HSCs and modified HSCs for use in clinical and basic science.
Methods: In the present review, we briefly summarized HSCs and their application in pathophysiologic conditions, including non-hematopoietic tissue regeneration as well as blood disorders.
Results: HSCs and HSCs-derived progenitors are promising cell sources in regenerative medicine and their contributions can be properly applied to treat pathophysiologic conditions.
Conclusions: Among many adult stem cells, HSCs are a powerful tool to treat patients with diseases such as hematologic malignancies and liver disease. Since HSCs can be differentiated into diverse progenitors including endothelial progenitors, they may be useful for constructing strategies for effective therapy.
Keywords : Hematopoietic stem cells, Stem cell therapy, Hematologic disorder, Liver disease

November 2019, 12 (3)