International Journal of Stem Cells : eISSN 2005-5447

Fig. 3.

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Fig. 3. Regulatory factors of 2OGDDs for HIF1α stabilization. Succinate, fumarate, and mitochondrial ROS inhibit PHD activation, leading to HIF1α stability. Conversely, 2OG, Fe2+, and ascorbate are required for PHD activation, followed by VHL-induced HIF1α ubiquitination. FIH is more sensitive to oxygen than VHL. Like PHD, ascorbate also activates FIH, which leads to asparaginyl hydroxylation, leading in turn to the destabilization of HIF1α.
International Journal of Stem Cells 2019;12:8-20 https://doi.org/10.15283/ijsc18109
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