International Journal of Stem Cells : eISSN 2005-5447

Table. 1.

Table. 1.

The studies of disease modeling in iPSCs-derived organoids

Organ Disease Induced cell types Modeling Reference
Lung Infection with respiratory syncytial virus Lung bud organoids (LBOs) For RSV infection of day 170 LBOs, 107 plaque-forming units (PFU) of RSV in 1 l was directly added onto each organoid and incubated for 3 h at 37℃. (14)
Fibrosis LBOs Mutation of HPS1 (14)
Infection with human para-influenza virus 3 (HPIV3) LBOs Recombinant HPIV3 for 32 days (15)
IPF Mesenchymal organoids 10 ng/ml TGF-β1 for 2 days (42)
Intestine Salmonellae (bacterial) infection intestinal organoids (iHO)-gut Add of 1×106 bacteria/well in 24 well (31)
Intestinal fibrosis iHO -mid/hindgut 2 ng/ml TGFβ for 96 hours (32)
Brain Zika virus infection Cerebral organoids ZIKV for 7 days (33)
Zika virus infection Neural organoids 3×105 PFU/ml 2 h at 37℃ (34)
Parkinson’s disease (PD) Midbrain-like organoids PD patient-derived organoids (35)
Alzheimer’s disease (AD) Neural organoids AD patient-derived organoids (36)
Liver Steatohepatitis (fibrosis with inflammation) Liver organoids 800 mM oleic acid (OA) for 7 days (37)
Infection with hepatitis B virus Hepatic organoids HBV (500, 5000 GEQ/cell) for 10 days (39)
International Journal of Stem Cells 2021;14:1-8 https://doi.org/10.15283/ijsc20093
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