International Journal of Stem Cells : eISSN 2005-5447

Table. 2.

Table. 2.

The role of OCT4-related complexes in cancer stem cells

Complex The role in cancer stem cells (CSCs)
OCT4/SOX2 complex Gene transcription, cell localization, DNA repair, cell cycle, apoptosis
Oct4/Sox2/Zfp206 complex Maintains stemness of CSCs
OCT4/SOX2/NANOG complex Inhibition of differentiation
Oct4/KLF4/β-catenin complex Maintains stemness of CSCs
OCT4/SALL4 complex Maintains stemness of CSCs
OCT4/Cav-1 complex Degradation of OCT4
OCT4/PKM2 complex Gene transcription
Ash2I/OSN complex Gene transcription
ABCG2/OCT4 complex Maintains stemness of CSCs
Oct4/Sox2/KLF4 complex The expression of Nanog
International Journal of Stem Cells 2020;13:312-25 https://doi.org/10.15283/ijsc20097
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