International Journal of Stem Cells : eISSN 2005-5447

Fig. 5.

Download original image
Fig. 5. SAG restored functional maturation of Cdo−/− ESC-derived motor neurons. (a∼c) Differential interference contrast (DIC) images and representative trace of a whole-cell current clamp recording from Cdo+/+ ESC-derived motor neurons, which were differentiatated with Shh (a) or Cdo−/− ESC-derived motor neurons, which were exposed to Shh (b) or SAG (c) for differentiation. (n=13 for Cdo+/+ (+Shh), n=9 for Cdo−/− (+Shh), n=8 for Cdo−/− (+SAG)) Scale bars=10 μm. (d∼i) Evoked action potentials generated in response to a depolarizing current injection. Graphs comparing the passive membrane properties. The sample size (n-number) is indicated in each graph. Values are means±SEM. *p<0.05, **p<0.01, ***p<0.001.
International Journal of Stem Cells 2020;13:342-52 https://doi.org/10.15283/ijsc20037
© 2020 International Journal of Stem Cells