International Journal of Stem Cells : eISSN 2005-5447

Fig. 4.

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Fig. 4. Analysis of RPE cells’ ability to resurface aged human Bruch’s membrane (BM) explants. (A, B) SEM micrography of the superficial structure of the BM’s illustrating exposition of the basement membrane layer. (C, D) ARPE-19 cells seeded and cultured on BM’s were not able to proliferate and the explant was only partially resurfaced; (E, F) hES- RPE cells seeded and cultured on BM’s were able to survive, proliferate and virtually resurface the whole explant, with small flaws (narrow arrows). hES-RPE formed a cell layer with a morphology that resembles the hexagonal character of native fetal RPE (wide arrows). *Represents an artifact occurred during manipulation of the sample.
International Journal of Stem Cells 2021;14:74-84 https://doi.org/10.15283/ijsc20094
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