International Journal of Stem Cells : eISSN 2005-5447

Table. 2.

Table. 2.

The effectiveness of exosomes/miRNAs as targets for mesodermal lineage disorders

Sources miRNAs In vitro In vivo References
BM-MSC miR-22 Reduce apoptosis in ischemic cardiomyocytes, ameliorated fibrosis and improve cardiac function post-myocardial infarction in mice (120)
miR-4532, miR-125b-5p, and miR-4516 Promote fracture healing in mice (121)
miR-494 Promote myogenesis and angiogenesis Promote muscle regeneration in mice (122)
miR-92a-3p Enhance chondrocyte proliferation, migration, and cartilage development Inhibit cartilage degradation in mice (151)
miR-135b Enhance chondrocyte proliferation Enhance chondrocyte proliferation in rat (152)
miR-885-5p Regulates BMP2-induced osteogenic differentiation (147)
miR-320c Enhance BMSC chondrogenesis (153)
miR-140-5p Promote adipocyte differentiation (154)
ASC miR-100-5p Inhibit cell apoptosis, promote anabolism in IL-1 β-induced chondrocytes, and enhance the level of autophagy Prevent the cartilage destruction (155)
Exert a major neuroprotective role (156)
Promote proliferation, migration, and osteogenic differentiation of BMSCs Promote bone regeneration in critical-sized calvarial defects in mice (157)
miR-218 Promote osteogenic differentiation (149)
Synovium-MSC miR-140-5p Activate YAP, decrease ECM secretion, and induce proliferation and migration of articular chondrocytes Slow the progression of early OA and prevent the severe damage of OA in rat (158)
iPSC-MSC Promote migration and proliferation of chondrocytes and hBMSCs Provide a mode for cartilage regeneration and promote integration (123)
Promote osteoblast proliferation, differentiation and bone formation Promote bone regeneration in critical-sized calvarial defects in rat (124)
Promote endothelial cell migration, proliferation, and tube formation Promote blood perfusion and attenuate severe hind-limb ischemia of mice (159)
Promote angiogenesis in endothelial cells Prevent bone loss and increase angiogenesis in rat (160)
International Journal of Stem Cells 2021;14:150-67 https://doi.org/10.15283/ijsc20167
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