International Journal of Stem Cells : eISSN 2005-5447

Fig. 2.

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Fig. 2. The activities of Nkx3.1. (A) The role of Nkx3.1 in the IL-6-STAT3 signalling pathway during iPSC in-duction. Nkx3.1 is a target of STAT3, downstream of IL6r activation and is essential during reprogramming. IL-6r deficiency during reprogramming is reported to be rescued by Nkx3.1 alone or in cooperation with STAT3. However, knockdown of STAT3 decreases Nkx3.1 protein level, whereas knockdown of Nkx3.1 blocks iPSC reprogramming (86). (B) Nkx3.1 can replace Oct4 in cellular reprogramming, and promotes the generation of iPSCs with a similar efficiency to Oct4.
International Journal of Stem Cells 2021;14:168-79 https://doi.org/10.15283/ijsc20121
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