International Journal of Stem Cells : eISSN 2005-5447

Fig. 3.

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Fig. 3. miR-324-5p-modified ADSCs enhance post-MI repair in rats. Note: MI model was established in rats via LAD, with ADSCs or miR-324-5p-modified ADSCs injected into the peri-MI area at multiple sites, with PBS injection as control. A, 28 days after ADSCs transplantation, myocardial function of rats was tested using echocardiography, N=12. B, after ultrasound detections, levels of cTnT and CK-MB in serum of rats were measured, N=12. C, MI degree in rats observed by HE staining. D, apoptosis in MI rats verified through TUNEL staining. N=6, the results of panels B and D were shown as mean±standard deviation. One-way ANOVA was used to analyze data in panels A, B and D. Tukey’s multiple comparisons test was applied for post hoc test. **p<0.01. MI: myocardial infarction, NC-ADSCs: ADSCs after lentivirus infection with miR-324-5p negative control, miR-ADSCs: ADSCs after lentivirus infection with miR-324-5p overexpression vectors.
International Journal of Stem Cells 2021;14:298-309 https://doi.org/10.15283/ijsc21025
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