International Journal of Stem Cells : eISSN 2005-5447

Fig. 5.

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Fig. 5. TOLLIP overexpression spoils the promotive role of miR-324-5p-modified ADSCs in post-MI repair in rats. Note: Ad-TOLLIP was injected in rats from the miR-ADSCs group, with Ad-NC as control. A, silencing efficiency of Ad-TOLLIP was verified by RT-qPCR. B, 28 days after ADSCs transplantation, myocardial function of rats were tested by echocardiography, N=12. C, levels of cTnT and CK-MB in serum of rats were measured, N=12. D, MI degree in rats was observed by HE staining. E, apoptosis in MI rats was verified through TUNEL staining. N=6, the results of panels C and E were shown as mean±standard deviation. One-way ANOVA was used to analyze data in panels A, B, C and E. Tukey’s multiple comparisons test was applied for post hoc test. **p<0.01. MI: myocardial infarction, NC-ADSCs: ADSCs after lentivirus infection with miR-324-5p negative control, miR-ADSCs: ADSCs after lentivirus infection with miR-324-5p overexpression vectors, Ad-TOLLIP: TOLLIP adenovirus.
International Journal of Stem Cells 2021;14:298-309 https://doi.org/10.15283/ijsc21025
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