International Journal of Stem Cells : eISSN 2005-5447

Fig. 4.

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Fig. 4. Circ-Gcap14 plays an important role in ADSC mediated diabetic wound closure. (A) RT-qPCR shows circ-Gcap14 expression in ADSCs upon circ-Gcap14 downregulation or overexpression/silencing. Data are presented as the mean±SD. ***p<0.001 vs. NC. ###p<0.001 vs. si-circ-Gcap14. (B, C) The rate of wound closure was quantified at indicated times after ADSC transplantation. Data are presented as the mean±SD. ***p<0.001 vs. hypoxic-ADSC. ###p<0.001 vs. si-circ-Gcap14-hypoxic-ADSC. (D, E) CD31 immunohistochemical staining detection the angiogenesis as black arrow show. Data are presented as the mean±SD. ***p<0.001 vs. hypoxic-ADSC. ###p<0.001 vs. si-circ-Gcap14-hypoxic-ADSC. (F, G) RT-qPCR and western blot detection shows the expression of HIF-1α and VEGF in both mRNA and protein level from tissue surrounding wounds. Data are presented as the mean±SD. ***p< 0.001 vs. hypoxic-ADSC. ###p<0.001 vs. si-circ-Gcap14-hypoxic-ADSC.
International Journal of Stem Cells 2021;14:447-54 https://doi.org/10.15283/ijsc21050
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