International Journal of Stem Cells : eISSN 2005-5447

Fig. 2.

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Fig. 2. (A) Therapeutic effects of HLSC transplantation in CCl4-induced liver fibrosis in rat model. Liver tissues were obtained from rats at 10 weeks (baseline) and at 14 weeks after initiation of CCl4 treatment (post 14w CCl4). Extracellular deposition of collagen fibers was stained with Sirius red. The presence of the transplanted HLSCs in the liver tissue was identified by immunohistoche-mistry using antibodies against human albumin (hALB). (B) Real-time qPCR analyses of ECM remodeling factors in rat liver specimens following two fibrosis induction protocols. Significant increase in MMP2, HGF expression and decrease in TIMP1, TIMP2 expression are seen following HLSC transplantation with intense toxicity protocol. These changes are not consistently observed in control groups.
International Journal of Stem Cells 2021;14:475-84 https://doi.org/10.15283/ijsc21031
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