International Journal of Stem Cells : eISSN 2005-5447

Fig. 6.

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Fig. 6. Bioinformatics analysis further reveals the characteristics of PSCs-derived EPCs. (A, B) Heatmap of EC-related genes from the 2D_MG_H1EC and 2D_MG_HUVEC datasets from GSE93511 and our microarray data in IPAH-EPCs (IPAH1, IPAH2, IPAH3), normal EPCs (Con1, Con2, Con3) and PSCs-derived EPCs (H7EC, H9EC, 202EC). PROM1, SPN and PTPRC were not expressed, and EFNB2 had a higher expression level in HUVECs (A), but PROM1, SPN and PTPRC were highly expressed in PSCs-derived EPCs, normal EPCs, IPAH-EPCs and 2D-MGH1EC (B). Moreover, EFNB2 also had a higher expression level in PSCs-derived EPCs than in normal EPCs and IPAH-EPCs (B). (C, D) Heatmap of homing-related genes from the 2D_MG_H1EC and 2D_MG_HUVEC datasets from GSE93511 and our microarray data in IPAH-EPCs (IPAH1, IPAH2, IPAH3), normal EPCs (Con1, Con2, Con3) and PSCs-derived EPCs (H7EC, H9EC, 202EC). IGF2, CXCL12 and CD90 (THY1) were not expressed in HUVECs (C), but had higher expression levels in PSCs-derived EPCs, normal EPCs, IPAH-EPCs (D) and 2D-MG-H1EC (C). IGFBP3 had a lower expression level in IPAH-EPCs than in PSCs-derived EPCs and normal EPCs (D).
International Journal of Stem Cells 2022;15:122-35 https://doi.org/10.15283/ijsc21044
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