International Journal of Stem Cells : eISSN 2005-5447

Fig. 1.

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Fig. 1. Schematic diagram summarizing the therapeutic strategies targeting oral CSCs. The diverse phenotypic heterogeneity and plasticity among cancer cells in bulk tumors have been explained by the CSC model of hierarchically organized tumors. Unlike bulk tumor cells, CSCs are intrinsically resistant to the majority of conventional chemotherapeutic agents; thus, the remaining CSC subpopulation can subsequently reconstitute tumors in patients with cellular heterogeneity.
International Journal of Stem Cells 2021;14:386-99 https://doi.org/10.15283/ijsc21084
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