International Journal of Stem Cells : eISSN 2005-5447

Fig. 2.

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Fig. 2. Schematic diagram summarizing the therapeutic strategies targeting oral CSC-specific surface markers or signaling pathways. Therapeutic efficiency could be enhanced by selectively targeting subtle expression differences in surface markers and alterations in various signaling regulators between CSC subpopulations and non-CSC subpopulations. For this reason, CSC markers can be used to identify CSC-enriched subpopulations and various therapeutic approaches effectively inhibit oral CSCs by targeting pluripotency-associated genes (ALDHs, CD44, CD133, and CD177) and CSC-specific signaling pathways (Wnt/β-catenin, Notch, and hedgehog signaling pathways).
International Journal of Stem Cells 2021;14:386-99
© 2021 International Journal of Stem Cells