International Journal of Stem Cells : eISSN 2005-5447

Fig. 4.

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Fig. 4. Postnatal development of neural stem cell population in the dentate gyrus of MNK mice. (A) Dentate gyrus sections from MNK and wild type mice were stained with NESTIN and SOX2 during postnatal brain development (P3∼P10). The white box indicates regions shown below (high magnification). Arrowheads indicate NESTIN+, SOX2+ neural stem cells. (B) Quantitative analysis of NESTIN+, SOX2+ cells during postnatal development of the DG. At P3, distribution of NESTIN+, SOX2+ cells in the dentate gyrus of MNK mice were not different from that of wild type. However, at P7 and P10, the number of NESTIN+, SOX2+ neural stem cells was significantly decreased in the SGZ of MNK mice. Scale bar 50 μm and 20 μm (high magnification). SGZ, subgranular zone; GCL, granule cell layer; ML, molecular layer. **p<0.001, n=4 each, by t-test.
International Journal of Stem Cells 2022;15:270-82 https://doi.org/10.15283/ijsc21088
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