International Journal of Stem Cells : eISSN 2005-5447

Fig. 8.

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Fig. 8. Graphic abstract. Working model of biphasic effect of modulating RA signaling on the enrichment differentiation of atrial-like and sinoatrial node-like cells based on the GiWi method. During the cardiac mesoderm stage of pan cardio-myocytes differentiation from hiPSCS, activation of RA signaling pathway promotes biased differentiation of atrial-like cells. In contrast, enrichment differentiation of sinoatrial node-like cells could be enabled by RA inhibition.
International Journal of Stem Cells 2022;15:247-57 https://doi.org/10.15283/ijsc21148
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