International Journal of Stem Cells : eISSN 2005-5447

Fig. 3.

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Fig. 3. Effects of hUCB-MSCs in an immune-stimulated environment. (A) HaCaT cells were co-cultured with hUCB-MSCs transfected with siCTL or siEGF under inflammatory conditions. Co-culture with hUCB-MSCs reduced mRNA levels of inflammatory cytokines (n=3). (B) Inhibitory effects of hUCB-MSCs on TARC secretion by TNF-α/IFN-γ-stimulated HaCaT cells (n=4). (C) hUCB-MSCs transfected with siCTL or siEGF were co-cultured with LAD2 cells for 48 h (n=3). (D) Th2 cells were co-cultured with hUCB-MSCs transfected with siCTL or siEGF under maturation conditions. Co-culture with hUCB-MSCs inhibited maturation of CD4/IL4 Th2 cells (n=4). NC: negative control, PC: positive control, MSC: mesenchymal stem cells. *p<0.05, **p<0.01, and ***p<0.001.
International Journal of Stem Cells 2022;15:311-23 https://doi.org/10.15283/ijsc21173
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