International Journal of Stem Cells : eISSN 2005-5447

Table. 1.

Table. 1.

NDDs and other neural disorders modeled so far using cerebral organoids

Neurodevelopment disorder modeled Modeled gene mutation/environmental condition Patient specific (PS)/
Genetically modified (GM)
References
Microcephaly WRD62 GM (15)
CDK5RAP2 PS (8)
CHMP1A GM (16)
Lissencephaly KATNB1 GM (17)
Miller Dieker Syndrome 17p13.3 deletion PS (18)
Macrocephaly PTEN GM (19)
(Seckel syndrome) CPAP PS (20)
Periventricular heteropia PLEKHG6 GM (21)
DCHS1 and FAT4 PS & GM (22)
Schizophrenia DISC1 GM (23)
16p13.11 microduplication PS (24)
FGFR1 PS (25)
Autism spectrum disorder CHD8 GM (26)
Down syndrome Trisomy 21 PS (27)
Rett syndrome MeCP2 PS (28)
GM1 gangliosidosis GLB1 GM (29)
GM2 gangliosidosis/Sandhoff disease HEXB PS (30)
Other neural disorders modeled
Alzheimer’s disease PSN1 PS (31)
APOE4 GM (32, 33)
Frontotemporal dementia MAPT PS (34)
Creutzfeldt-Jakob disease Exposure to CJD prion subtypes PS (35)
Hereditary spastic paraplegia SPG11 PS (36)
Huntington’s disease HTT PS (37)
International Journal of Stem Cells 2022;15:26-40 https://doi.org/10.15283/ijsc22006
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