International Journal of Stem Cells : eISSN 2005-5447

Table. 2.

Table. 2.

Advantages and disadvantages of biomaterials for organoid culture.

Matrigel Natural polymers dECM Synthetic polymers
Advantages

Built-in complex mixture of nutrients and proteins

Readily available commercialized product

Easy to handle

Inertness

Low toxicity

Biodegradability

Low toxicity

Closely mimics native ECM

High bioactivity

Biodegradability

Chemically defined

Xenogeneic-free

Tunable mechanical and degradation properties

Disadvantages

Not clinically applicable

Poorly defined

Low mechanical strength

Lot-to-lot variability

Lacks tissue-specific ECM compositions

Low mechanical strength

Lacks tissue-specific ECM compositions

Poorly defined

Low mechanical strength

Rapid degradation

Low bioactivity

Low cell adhesion

Lacks tissue-specific ECM compositions

Difficult and expensive synthesis procedure

International Journal of Stem Cells 2022;15:60-9 https://doi.org/10.15283/ijsc21190
© 2022 International Journal of Stem Cells