International Journal of Stem Cells : eISSN 2005-5447

Table. 3.

Table. 3.

IC50 (MTT and MEA)

Material IC50 values (MTT) LOEC (MTT) IC50 values (MEA) LOEC (MEA) Comparison value
Neurotransmitter
L-glutamic acid 157.6 mM 10 mM 46.6 μM 100 μM 338594
GABA 60.6 mM 30 mM 11.5 μM 10 μM 525854
Epinephrine 59 μM 100 μM 2.8 μM 100 μM 2117
Dopamine 118.7 μM 100 μM 9.8 μM 10 μM 1208
Serotonin 2.7 mM 3 mM 15.4 μM 10 μM 17625
Acetylcholine 426.5 mM 30 mM 13.5 μM 30 μM 3165766
Neurotoxicant
D-AP5 - - 153.9 μM 100 μM
CNQX 383.6 μM 100 μM 87.1 μM 50 μM 440
Bicuculline 2.6 mM 125 μM 15.9 μM 30 μM 16521
Tetrodotoxin - - 5.5 nM 0.03 μM
4-Aminopyridine - - 14.7 μM 10 μM
Tetraethylammonium chloride 230.6 mM 100 mM 12.4 mM 10 mM 1865
Illicit drug
Methamphetamine 2.9 mM 3 mM 300.5 μM 300 μM 959
Cocaine 18.1 mM 3 mM 11 μM 10 μM 164062
Tetrahydrocannabinol 2.9 mM 3 mM 8.1 μM 30 μM 36039
NPS
3,4-Dicloromethylphenidate 230.6 μM 6.25 μM 23.5 μM 15.6 μM 981
LY-2183240 153.7 μM 50 μM 59.2 μM 50 μM 260
4-EA-NBOMe 5.1 μM 3 μM 4.3 nM 3 nM 117709
AB-CHFURYCA 93.6 μM 30 μM 11.3 μM 30 μM 831

LOEC: lowest observed effect concentration.

Comparison value: (IC50 values [MTT]/IC50 values [MEA])*100.

International Journal of Stem Cells 2022;15:258-69 https://doi.org/10.15283/ijsc21217
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