Fig. 6. The effects of SHED (MIRB-labeled and unlabeled) on bone regeneration (A). HE staining of the defected area 4 weeks after surgery. (A’) The higher magnified images in the boxed regions of (A). (B) Quantitative analysis of newly formed bone areas in four groups by HE staining. (C) Immunohistochemical staining of OCN 4 weeks after surgery. (C’) The higher magnified images in the boxed regions of (C). (D) Quantitative analysis of OCN expression in four groups. (E) Immunohistochemical staining of Runx2 2 weeks after surgery. (E’) The higher magnified images in the boxed regions of (E). (F) Comparison of the number of Runx2^＋ cells in four groups. The black scale bars represent 100 μm, and the white scale bars represent 50 μm. NS: not significant. *p<0.05, **p<0.01.

International Journal of Stem Cells 2023;16:93-107 https://doi.org/10.15283/ijsc21204

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