Fig. 2. Schematic illustration of angiogenesis and related signaling path-ways. (A) The angiogenesis process. (B) Signaling pathways in tip cell/stalk cell specification. EC: endothelial cell, BM: basement membrane, VE-cadherin: vascular endothelial cadherin, VEGF: vascular endothelial growth factor, VEGFR: VEGF receptor, DLL: Delta-like ligand, NICD: Notch intracellular domain.
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