International Journal of Stem Cells : eISSN 2005-5447

Fig. 2.

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Fig. 2. Endothelial cells and hematopoietic cells engage in crosstalk. (A) During embryonic development, the hemangioblast gives rise to endothelial and hematopoietic cells, leading to essential crosstalk between these cell types. This interaction regulates blood flow, vessel growth, and barrier formation. Hematopoietic cells derived from the hemangioblast serve as the source of blood cells. These interactions tightly control vascular development, blood cell production, and hemostasis. (B) Three stages of primitive, pro-definitive and definitive hematopoietic cell production generate cohorts of hematopoietic cells that are required for early embryogenesis. Primitive and pro-definitive wave leads to largely transient erythroid and myeloid progenitors (EMPs) that are necessary to support embryonic development. A subset of EMPs generated from pro-definitive wave are long-lived and differentiate into tissue-resident macrophages and microglia in the brain. The definitive wave leads to generation of hematopoietic stem cells (HSCs) from hemogenic endothelial cells in the dorsal aorta that migrate to fetal liver. These self-renewing HSCs subsequently migrate to bone marrow (BM) around birth and give rise adult lineages of hematopoietic cells in the BM niche.
International Journal of Stem Cells 2024;17:15-29
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