A summary of characteristics of 2D and 3D culture models
2D (mono-layer) | 3D organoid | 3D bioprinting | Reference | |
---|---|---|---|---|
Mimicry of native tissue structure | Low | Intermediate | High | (3) |
Maturity | Low | Intermediate | High | (4) |
Cell-ECM interaction | 2D | 3D | Controlled 3D | (5) |
Cell-cell interaction | 2D | 3D | Controlled 3D | (6) |
Throughput | ∼102 | ∼102 | >103 | (7) |
ECM: extracellular matrix.