Overview of key studies on quiescent stem cells
| Suggested markers | Used lineage tracing model | Position | Contribution | Reference | ||
|---|---|---|---|---|---|---|
| Homeostasis | Regeneration (damage type) | Tumorigenesis | ||||
| Bmi1 | Bmi1LacZ Bmi1DTA | ＋4, ＋5 | Y | Y (irradiation) | Y (inducer) | (20) |
| Mex3a | Mex3atdTomato | ＋1∼＋4 | Y | Y (irradiation, 5-FU) | ND | (21) |
| Sox9 | Sox9GFP | ＋4 | N | Y (irradiation) | ND | (22) |
| Lrig1 | Lrig1LacZ | ＋1∼＋5 | Y | Y (irradiation) | Y (repressor) | (23) |
| Hopx | HopxLacZ HopxmT-mG | ＋4 | Y | ND | ND | (24) |
| mTert | mTertGFP mTertLacZ | ＋4 | Y | Y (irradiation) | ND | (25) |
| Bmi1 |
Bmi1LacZ Bmi1Confetti | ＋4/＋5 | Y | ND | ND | (26) |
| Sox9 | Sox9GFP | ＋4/＋5 | ND | Y (irradiation) | ND | (29) |
| Bmi1 Prox1 |
Bmi1YFP Prox1GFP | ＋4 | N | Y (irradiation) | ND | (32) |
| Bmi1 Hopx |
H2BGFP HopxtdTomato | ＋3∼＋7 | N | Y (irradiation) | ND | (34) |
| NeuroD1 Tph1 Hopx |
NeuroD1tdTomato Tph1tdTomato HopxtdTomato | ＋4 | Y | Y (irradiation) | ND | (37) |
| p57 Bmi1 |
P57tdTomato Bmi1GFP | ＋4 | ND | Y (irradiation, Lgr5 ablation, 5-FU) | Y (inducer) | (38) |
Bmi1: B cell-specific Moloney murine leukemia virus integration site 1, Mex3a: mex-3 RNA binding family member A, Sox9: SRY-box transcription factor 9, Lrig1: leucine-rich repeats and immunoglobulin-like domains 1, Hopx: HOP homeobox, mTert: mouse telomerase reverse transcriptase, Prox1: prospero homeobox 1, NeuroD1: neurogenic differentiation 1, Tph1: tryptophan hydroxylase 1, Y: yes, N: no, ND: not determined, 5-FU: 5-fluorouracil, Lgr5: leucine-rich repeat-containing G protein-coupled receptor 5.