Fig. 4. Phenotype of 3D-WJ-CM cream-treated psoriasis-like mice. Mice were randomly divided into five groups: normal, IMQ＋vehicle, IMQ＋MTX, IMQ＋2D-WJ-CM, and IMQ＋3D-WJ-CM groups. (A) Two representative photographs of mice phenotypes before sacrifice. (B) In the back skin of BALB/c mice, the thickness, erythema, and scaling were scored from 0∼4 points from the start of treatment to the date of sacrifice. In addition, the cumulative score combining thickness, erythema, and scaling was presented. Symbols represent the mean standard deviation of six mice. IMQ: imiquimod, MTX: methotrexate, 2D: two-dimensional, WJ: Wharton’s jelly, CM: conditioned media, 3D: three-dimensional. Two-way ANOVA showed significant differences between groups, ^###p<0.001, ^####p<0.0001 compared to Vehicle and 3D-WJ-CM. *p<0.05, **p<0.01, ***p<0.001 compared to 2D-WJ-CM and 3D-WJ-CM.