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Human Endometrial Regenerative Cells for Neurological Disorders: Hype or Hope?
International Journal of Stem Cells
Published online January 8, 2024;  
© 2024 Korean Society for Stem Cell Research.

Javad Momeni1,2,3,4,*, Elnaz Naserzadeh4,*, Ali Sepehrinezhad5, Rezan Ashayeri Ahmadabad3, Sajad Sahab Negah1,2,3

1Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
2Department of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran
4Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
5Department of Neuroscience, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
Correspondence to: Sajad Sahab Negah
Neuroscience Research Center, Mashhad University of Medical Sciences, Pardis Campus, Azadi Square, Kalantari Blvd., Mashhad 91331, Iran
*These authors contributed equally to this work.
Received June 15, 2023; Revised August 28, 2023; Accepted October 6, 2023.
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Despite enormous efforts, no effective medication has been found to significantly halt or even slow the progression of neurological diseases, such as acquired (e.g., traumatic brain injury, spinal cord injury, etc.) and chronic (e.g., Parkinson’s disease, Alzheimer’s disease, etc.) central nervous system disorders. So, researchers are looking for alternative therapeutic modalities to manage the disease’s symptoms and stop it from worsening. Concerning disease-modifying capabilities, stem cell therapy has emerged as an expanding domain. Among different types of stem cells, human endometrial regenerative cells have excellent regenerative properties, making them suitable for regenerative medicine. They have the potential for self-renewal and differentiation into three types of stem cells: epithelial stem cells, endothelial side population stem cells, and mesenchymal stem cells (MSCs). ERCs can be isolated from endometrial biopsy and menstrual blood samples. However, there is no comprehensive evidence on the effects of ERCs on neurological disorders. Hence, we initially explore the traits of these specific stem cells in this analysis, followed by an emphasis on their therapeutic potential in treating neurological disorders.
Keywords : Stem cell transplantation, Central nervous system diseases, Endometrium, Regenerative medicine

May 2024, 17 (2)
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