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The Role of Exosomes from Mesenchymal Stem Cells in Spinal Cord Injury: A Systematic Review
International Journal of Stem Cells
Published online November 29, 2023;  
© 2023 Korean Society for Stem Cell Research.

Haoyu Wang1, Chunxia Zhao1, Qingqing Rong1, Jinghe Cao2, Hongyi Chen3, Ruolin Li1, Bin Zhang4, Peng Xu1

1Department of Neurology, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, China
2Department of Reproduce, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, China
3Department of Gastrointestinal Surgery, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, China
4Institute of Forensic Medicine and Laboratory Medicine, Jining Medical University, Jining, China
Correspondence to: Peng Xu
Department of Neurology, Affiliated Hospital of Jining Medical University, Jining Medical University, 89 Guhuai Road, Jining 272007, China
E-mail: jyfyxp@126.com
Co-Correspondence to Bin Zhang
Institute of Forensic Medicine and Laboratory Medicine, Jining Medical University, 89 Guhuai Road, Jining 272000, China
E-mail: zhb861109@163.com
Received June 15, 2023; Revised September 7, 2023; Accepted September 18, 2023.
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Spinal cord injury (SCI) is a serious nervous system disease that usually leads to the impairment of the motor, sensory, and autonomic nervous functions of the spinal cord, and it places a heavy burden on families and healthcare systems every year. Due to the complex pathophysiological mechanism of SCI and the poor ability of neurons to regenerate, the current treatment scheme has very limited effects on the recovery of spinal cord function. In addition, due to their unique advantages, exosomes can be used as carriers for cargo transport. In recent years, some studies have confirmed that treatment with mesenchymal stem cells (MSCs) can promote the recovery of SCI nerve function. The therapeutic effect of MSCs is mainly related to exosomes secreted by MSCs, and exosomes may have great potential in SCI therapy. In this review, we summarized the repair mechanism of mesenchymal stem cells-derived exosomes (MSCs-Exos) in SCI treatment and discussed the microRNAs related to SCI treatment based on MSCs-Exos and their mechanism of action, which is helpful to further understand the role of exosomes in SCI.
Keywords : Spinal cord injury, Mesenchymal stem cells, Exosomes, miRNA, Delivery vehicles


May 2024, 17 (2)
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