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In Vivo Stem Cell Imaging Principles and Applications
International Journal of Stem Cells
Published online August 30, 2023;  
© 2023 Korean Society for Stem Cell Research.

Seongje Hong1, Dong-Sung Lee2, Geun-Woo Bae1, Juhyeong Jeon1, Hak Kyun Kim3, Siyeon Rhee4, Kyung Oh Jung1

1Department of Anatomy, College of Medicine, Chung-Ang University, Seoul, Korea,
2Department of Life Sciences, University of Seoul, Seoul, Korea,
3Department of Life Science, Chung-Ang University, Seoul, Korea,
4Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA
Correspondence to: Kyung Oh Jung
Department of Anatomy, College of Medicine, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 06974, Korea
Received April 15, 2023; Revised July 13, 2023; Accepted July 21, 2023.
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Stem cells are the foundational cells for every organ and tissue in our body. Cell-based therapeutics using stem cells in regenerative medicine have received attracting attention as a possible treatment for various diseases caused by congenital defects. Stem cells such as induced pluripotent stem cells (iPSCs) as well as embryonic stem cells (ESCs), mesenchymal stem cells (MSCs), and neuroprogenitors stem cells (NSCs) have recently been studied in various ways as a cell-based therapeutic agent. When various stem cells are transplanted into a living body, they can differentiate and perform complex functions. For stem cell transplantation, it is essential to determine the suitability of the stem cell-based treatment by evaluating the origin of stem, the route of administration, in vivo bio-distribution, transplanted cell survival, function, and mobility. Currently, these various stem cells are being imaged in vivo through various molecular imaging methods. Various imaging modalities such as optical imaging, magnetic resonance imaging (MRI), ultrasound (US), positron emission tomography (PET), and single-photon emission computed tomography (SPECT) have been introduced for the application of various stem cell imaging. In this review, we discuss the principles and recent advances of in vivo molecular imaging for application of stem cell research.
Keywords : Stem cells, In vivo molecular imaging, Optical imaging, Magnetic resonance imaging, Positron emission tomography, Single-photon emission computed tomography

August 2023, 16 (3)
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