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Lung Organoid on a Chip: A New Ensemble Model for Preclinical Studies
International Journal of Stem Cells
Published online October 11, 2023;  
© 2023 Korean Society for Stem Cell Research.

Hyung-Jun Kim1,2, Sohyun Park1,2, Seonghyeon Jeong2, Jihoon Kim3, Young-Jae Cho1,2

1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
2Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
3Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Korea
Correspondence to: Young-Jae Cho
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, 82 Gumi-ro 173beon-gil, Bundang-gu, Seongnam 13620, Korea
E-mail: lungdrcho@snu.ac.kr
Co-Correspondence to Jihoon Kim
Department of Medical and Biological Sciences, The Catholic University of Korea, 327 Sosa-ro, Bucheon 14647, Korea
E-mail: jhkim@catholic.ac.kr
Received June 15, 2023; Revised August 5, 2023; Accepted September 8, 2023.
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
The lung is a complex organ comprising a branched airway that connects the large airway and millions of terminal gas-exchange units. Traditional pulmonary biomedical research by using cell line model system have limitations such as lack of cellular heterogeneity, animal models also have limitations including ethical concern, race-to-race variations, and physiological differences found in vivo. Organoids and on-a-chip models offer viable solutions for these issues. Organoids are three-dimensional, self-organized construct composed of numerous cells derived from stem cells cultured with growth factors required for the maintenance of stem cells. On-a-chip models are biomimetic microsystems which are able to customize to use microfluidic systems to simulate blood flow in blood channels or vacuum to simulate human breathing. This review summarizes the key components and previous biomedical studies conducted on lung organoids and lung-on-a-chip models, and introduces potential future applications. Considering the importance and benefits of these model systems, we believe that the system will offer better platform to biomedical researchers on pulmonary diseases, such as emerging viral infection, progressive fibrotic pulmonary diseases, or primary or metastatic lung cancer.
Keywords : Lung, Pulmonary diseases, Organoids, Microphysiological systems


November 2023, 16 (4)
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