Immune-Epithelial Cell Interactions during Epidermal Regeneration, Repair, and Inflammatory Diseases
Axel D. Schmitter-Sánchez1,2, Sangbum Park1,3,4
1Institute for Quantitative Health Science and Engineering (IQ), Michigan State University, East Lansing, MI, USA
2Cell and Molecular Biology Program, College of Natural Science, Michigan State University, East Lansing, MI, USA
3Division of Dermatology, Department of Medicine, College of Human Medicine, Michigan State University, East Lansing, MI, USA
4Department of Pharmacology and Toxicology, College of Human Medicine, Michigan State University, East Lansing, MI, USA
2Cell and Molecular Biology Program, College of Natural Science, Michigan State University, East Lansing, MI, USA
3Division of Dermatology, Department of Medicine, College of Human Medicine, Michigan State University, East Lansing, MI, USA
4Department of Pharmacology and Toxicology, College of Human Medicine, Michigan State University, East Lansing, MI, USA
Correspondence to: Sangbum Park
Department of Medicine, College of Human Medicine, Michigan State University, 775 Woodlot Drive, IQ Building, East Lansing, MI 48824, USA
E-mail: spark@msu.edu
Department of Medicine, College of Human Medicine, Michigan State University, 775 Woodlot Drive, IQ Building, East Lansing, MI 48824, USA
E-mail: spark@msu.edu
Received July 7, 2023; Revised November 9, 2023; Accepted December 4, 2023.
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Abstract
- The multiple layers of the skin cover and protect our entire body. Among the skin layers, the epidermis is in direct contact with the outer environment and serves as the first line of defense. The epidermis functions as a physical and immunological barrier. To maintain barrier function, the epidermis continually regenerates and repairs itself when injured. Interactions between tissue-resident immune cells and epithelial cells are essential to sustain epidermal regeneration and repair. In this review, we will dissect the crosstalk between epithelial cells and specific immune cell populations located in the epidermis during homeostasis and wound repair. In addition, we will analyze the contribution of dysregulated immune-epithelial interactions in chronic inflammatory diseases.
- Keywords : Epidermis, Keratinocytes, Dendritic cells, Cell communication, Wound healing, Skin diseases
- November 2024, 17 (4)
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