Crosstalk between Signaling Pathways and Energy Metabolism in Pluripotency
Keun-Tae Kim1,*, Seong-Min Kim2,*, Hyuk-Jin Cha2
1Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan
2College of Pharmacy, Seoul National University, Seoul, Korea
2College of Pharmacy, Seoul National University, Seoul, Korea
Correspondence to: Hyuk-Jin Cha
College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea
E-mail: hjcha93@snu.ac.kr
*These authors contributed equally to this work.
College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea
E-mail: hjcha93@snu.ac.kr
*These authors contributed equally to this work.
Received November 3, 2023; Revised January 8, 2024; Accepted February 14, 2024.
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Abstract
- The sequential change from totipotency to multipotency occurs during early mammalian embryo development. However, due to the lack of cellular models to recapitulate the distinct potency of stem cells at each stage, their molecular and cellular characteristics remain ambiguous. The establishment of isogenic naïve and primed pluripotent stem cells to represent the pluripotency in the inner cell mass of the pre-implantation blastocyst and in the epiblast from the post-implantation embryo allows the understanding of the distinctive characteristics of two different states of pluripotent stem cells. This review discusses the prominent disparities between naïve and primed pluripotency, including signaling pathways, metabolism, and epigenetic status, ultimately facilitating a comprehensive understanding of their significance during early mammalian embryonic development.
- Keywords : Naïve pluripotent stem cells, Primed pluripotent stem cells, Signaling pathways, Cellular metabolism, Early embryo development, Pluripotent stem cells
- November 2024, 17 (4)
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